Bruker Daltonics, March 2020

This issue is a recap of Bruker's solutions in the area of 4D-Proteomics, 4D-Metabolomics, 4D-Lipidomics and SpatialOMx® that we hope you had the opportunity to read and share with the Life Science Community.  

Breakthrough dia-PASEF workflow for CCS-aware 4D-Proteomics
A new approach revolutionizes the proteomics market. The timsTOF Pro known for its high speed, sensitivity and robustness combined with dia-PASEF offers new possibilities in the field of 4D-Proteomics. Watch the video to learn more from Dr. Hannes Röst, University of Toronto and Prof. Ruedi Aebersold from the ETH Zurich about the perfect match of timsTOF Pro and dia-PASEF.

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Applying a Proteomics-based approach to the clinic with Matthias Mann
In this interview, Professor Matthias Mann discusses his work in the field of proteomics, and explains why applying proteomics-based technologies such as timsTOF to clinical research could accelerate the diagnosis and prediction of human disease.

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PASEF for 4D-Lipidomics
PASEF takes advantage of the temporal separation of ions eluting from the TIMS device to select multiple precursors for MS/MS acquisition in a single TIMS scan. This Nature Communications article shows how using the timsTOF Pro for in-depth lipidomics can benefit from using >1800 lipid TIMS CCS values. 

Link to full article

CCSPredict:  Using a machine learning approach for higher confidence in lipid identification 
Trapped ion mobility (TIMS) mass spectrometers offer new options for higher confidence in annotations of target lipids. With the additional TIMS separation dimension, compounds co-eluting from LC columns can be separated. This can result in cleaner MS/MS spectra – crucial for any ID in lipidomics or other small molecule workflows. Moreover, TIMS enables the determination of collisional cross sections (CCS) of ions.

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SpatialOMx delivers a more complete picture for tissue-based X-Omics analyses
Ever thought about the advantages to combine different mass spectrometry techniques for a better understanding of diseases? The timsTOF fleX, a timsTOF Pro Q-TOF equippped with a fully integrated high speed, high spatial resolution MALDI source, provides researchers a single integrated platform for using MALDI as a molecular GPS to deliver greater cellular spcificity for X-Omics analyses.

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Novel workflow solution for automatically annotating MALDI Imaging data 
MALDI Imaging spectra can be used to investigate how compounds are localized across tissue samples. In this application note, we present a novel software workflow for the identification of signals using data from the high-speed, high spatial resolution of the timsTOF fleX instrument.  

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